2,656 research outputs found
Diagnosis of helminths depends on worm fecundity and the distribution of parasites within hosts
Helminth transmission and morbidity are dependent on the number of mature parasites within a host; however, observing adult worms is impossible for many natural infections. An outstanding challenge is therefore relating routine diagnostics, such as faecal egg counts, to the underlying worm burden. This relationship is complicated by density-dependent fecundity (egg output per worm reduces due to crowding at high burdens) and the skewed distribution of parasites (majority of helminths aggregated in a small fraction of hosts). We address these questions for the carcinogenic liver fluke Opisthorchis viverrini, which infects approximately 10 million people across Southeast Asia, by analysing five epidemiological surveys (n = 641) where adult flukes were recovered. Using a mechanistic model, we show that parasite fecundity varies between populations, with surveys from Thailand and Laos demonstrating distinct patterns of egg output and density-dependence. As the probability of observing faecal eggs increases with the number of mature parasites within a host, we quantify diagnostic sensitivity as a function of the worm burden and find that greater than 50% of cases are misdiagnosed as false negative in communities close to elimination. Finally, we demonstrate that the relationship between observed prevalence from routine diagnostics and true prevalence is nonlinear and strongly influenced by parasite aggregation
Assessing the efficiency of mother-to-child HIV prevention in low- and middle-income countries using data envelopment analysis
AIDS is one of the most significant health care problems worldwide. Due to the difficulty and costs involved in treating HIV, preventing infection is of paramount
importance in controlling the AIDS epidemic. The main purpose of this paper is to explore the potential of using Data Envelopment Analysis (DEA) to establish international
comparisons on the efficiency of implementation of HIV prevention programmes. To do this we use data from 52 low- and middle-income countries regarding
the prevention of mother-to-child transmission of HIV.
Our results indicate that there is a remarkable variation in the efficiency of prevention services across nations,
suggesting that a better use of resources could lead to more and improved services, and ultimately, prevent the infection of thousands of children. These results also
demonstrate the potential strategic role of DEA for the efficient and effective planning of scarce resources to fight the epidemic
Quenching Factor for Low Energy Nuclear Recoils in a Plastic Scintillator
Plastic scintillators are widely used in industry, medicine and scientific
research, including nuclear and particle physics. Although one of their most
common applications is in neutron detection, experimental data on their
response to low-energy nuclear recoils are scarce. Here, the relative
scintillation efficiency for neutron-induced nuclear recoils in a
polystyrene-based plastic scintillator (UPS-923A) is presented, exploring
recoil energies between 125 keV and 850 keV. Monte Carlo simulations,
incorporating light collection efficiency and energy resolution effects, are
used to generate neutron scattering spectra which are matched to observed
distributions of scintillation signals to parameterise the energy-dependent
quenching factor. At energies above 300 keV the dependence is reasonably
described using the semi-empirical formulation of Birks and a kB factor of
(0.014+/-0.002) g/MeVcm^2 has been determined. Below that energy the measured
quenching factor falls more steeply than predicted by the Birks formalism.Comment: 8 pages, 9 figure
WIMP-nucleon cross-section results from the second science run of ZEPLIN-III
We report experimental upper limits on WIMP-nucleon elastic scattering cross
sections from the second science run of ZEPLIN-III at the Boulby Underground
Laboratory. A raw fiducial exposure of 1,344 kg.days was accrued over 319 days
of continuous operation between June 2010 and May 2011. A total of eight events
was observed in the signal acceptance region in the nuclear recoil energy range
7-29 keV, which is compatible with background expectations. This allows the
exclusion of the scalar cross-section above 4.8E-8 pb near 50 GeV/c^2 WIMP mass
with 90% confidence. Combined with data from the first run, this result
improves to 3.9E-8 pb. The corresponding WIMP-neutron spin-dependent
cross-section limit is 8.0E-3 pb. The ZEPLIN programme reaches thus its
conclusion at Boulby, having deployed and exploited successfully three liquid
xenon experiments of increasing reach
Single electron emission in two-phase xenon with application to the detection of coherent neutrino-nucleus scattering
We present an experimental study of single electron emission in ZEPLIN-III, a
two-phase xenon experiment built to search for dark matter WIMPs, and discuss
applications enabled by the excellent signal-to-noise ratio achieved in
detecting this signature. Firstly, we demonstrate a practical method for
precise measurement of the free electron lifetime in liquid xenon during normal
operation of these detectors. Then, using a realistic detector response model
and backgrounds, we assess the feasibility of deploying such an instrument for
measuring coherent neutrino-nucleus elastic scattering using the ionisation
channel in the few-electron regime. We conclude that it should be possible to
measure this elusive neutrino signature above an ionisation threshold of
3 electrons both at a stopped pion source and at a nuclear reactor.
Detectable signal rates are larger in the reactor case, but the triggered
measurement and harder recoil energy spectrum afforded by the accelerator
source enable lower overall background and fiducialisation of the active
volume
Policy Recommendations From Transmission Modeling for the Elimination of Visceral Leishmaniasis in the Indian Subcontinent.
Background: Visceral leishmaniasis (VL) has been targeted by the World Health Organization (WHO) and 5 countries in the Indian subcontinent for elimination as a public health problem. To achieve this target, the WHO has developed guidelines consisting of 4 phases of different levels of interventions, based on vector control through indoor residual spraying of insecticide (IRS) and active case detection (ACD). Mathematical transmission models of VL are increasingly used for planning and assessing the efficacy of interventions and evaluating the intensity and timescale required to achieve the elimination target. Methods: This paper draws together the key policy-relevant conclusions from recent transmission modeling of VL, and presents new predictions for VL incidence under the interventions recommended by the WHO using the latest transmission models. Results: The model predictions suggest that the current WHO guidelines should be sufficient to reach the elimination target in areas that had medium VL endemicities (up to 5 VL cases per 10000 population per year) prior to the start of interventions. However, additional interventions, such as extending the WHO attack phase (intensive IRS and ACD), may be required to bring forward elimination in regions with high precontrol endemicities, depending on the relative infectiousness of different disease stages. Conclusions: The potential hurdle that asymptomatic and, in particular, post-kala-azar dermal leishmaniasis cases may pose to reaching and sustaining the target needs to be addressed. As VL incidence decreases, the pool of immunologically naive individuals will grow, creating the potential for new outbreaks
Defining and Detecting Crossover-Interference Mutants in Yeast
The analysis of crossover interference in many creatures is complicated by the presence of two kinds of crossovers, interfering and noninterfering. In such creatures, the values of the traditional indicators of interference are subject not only to the strength of interference but also to the relative frequencies of crossing over contributed by the two kinds. We formalize the relationship among these variables and illustrate the possibilities and limitations of classical interference analysis with meiotic tetrad data from wild-type Saccharomyces cerevisiae and from mlh1 and ndj1 mutants
Policy Recommendations From Transmission Modeling for the Elimination of Visceral Leishmaniasis in the Indian Subcontinent.
Background: Visceral leishmaniasis (VL) has been targeted by the World Health Organization (WHO) and 5 countries in the Indian subcontinent for elimination as a public health problem. To achieve this target, the WHO has developed guidelines consisting of 4 phases of different levels of interventions, based on vector control through indoor residual spraying of insecticide (IRS) and active case detection (ACD). Mathematical transmission models of VL are increasingly used for planning and assessing the efficacy of interventions and evaluating the intensity and timescale required to achieve the elimination target. Methods: This paper draws together the key policy-relevant conclusions from recent transmission modeling of VL, and presents new predictions for VL incidence under the interventions recommended by the WHO using the latest transmission models. Results: The model predictions suggest that the current WHO guidelines should be sufficient to reach the elimination target in areas that had medium VL endemicities (up to 5 VL cases per 10000 population per year) prior to the start of interventions. However, additional interventions, such as extending the WHO attack phase (intensive IRS and ACD), may be required to bring forward elimination in regions with high precontrol endemicities, depending on the relative infectiousness of different disease stages. Conclusions: The potential hurdle that asymptomatic and, in particular, post-kala-azar dermal leishmaniasis cases may pose to reaching and sustaining the target needs to be addressed. As VL incidence decreases, the pool of immunologically naive individuals will grow, creating the potential for new outbreaks
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